German: Pickardt-Syndrom
Pickardt Syndrome is a rare form of tertiary Hypothyroidism that is caused by interruption of portal vessels connecting hypothalamus and pituitary. This typically origines in tumor or thrombosis. In the consequence, an inadequately low amount of TRH reaches the anterior pituitary lobe and hence release of TSH is very low, leading to understimulation of the thyroid with hypothyroidism, in spite of functional thyrotropic feedback control.
Other endocrine dysfunctions associated with Pickardt's Syndrome are suprasellar malfunctions like secondary hypogonadism or hyperprolactinemia.
Reference
- Pickardt, C. R.; Erhardt, F.; Fahlbusch, R. and Scriba, P. C. (1973): Portal Vessels Occlusion. A Cause for Pituitary Insufficiency in Patiens with Pituitary Tumors. European Journal of Clinical Investigation. 3: 262
