Homeostasis model assessment (HOMA) is a diagnostical procedure that is based on the
homeostasis model of
carbohydrate metabolism.
The HOMA approach is grounded in the
homeostasis model of Turner et al., a mathematical model of
feedback coupled interaction of insulin and glucose in
carbohydrate homeostasis.
In HOMA, simultaneously determined
glucose and
insulin levels in fasting state are entered in equations that calculate
beta cell function and
insulin sensitivity.
- HOMA Beta = 20 * fasting insulin (mU/l) / (fasting glucose (mmol/l) - 3,5)
- HOMA IR = fasting insulin (mU/l) * fasting glucose (mmol/l) / 22,5
Alternative approaches are:
- Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985 Jul;28(7):412
- Mehmet Keskin, Selim Kurtoglu, Mustafa Kendirci, M. Emre Atabek und Cevat Yazici. Homeostasis Model Assessment Is More Reliable Than the Fasting Glucose/Insulin Ratio and Quantitative Insulin Sensitivity Check Index for Assessing Insulin Resistance Among Obese Children and Adolescents. Pediatrics 115 No. 4 April 2005, pp. e500-e503 (doi:10.1542/peds.2004-1921)
- Yiqing Song, JoAnn E. Manson, Lesley Tinker, Barbara V. Howard, Lewis H. Kuller, Lauren Nathan, Nader Rifai und Simin Liu. Insulin Sensitivity and Insulin Secretion Determined by Homeostasis Model Assessment and Risk of Diabetes in a Multiethnic Cohort of Women. Diabetes Care 30:1747-1752, 2007 (doi: 10.2337/dc07-0358)
