DCCC is an abbreviation for the
Diabetes Control and Complications Trial. This study has conclusively proven that intensified
insulin therapy improves long-term glycemic control as measured by
HbA1c fraction, and reduces the risk of development and progression of microvascular complications; the major drawback being 2-3 fold increase in severe
hypoglycemic episodes.
- The Diabetes Control and Complications Trial Research Group (1993), The effect of intensive therapy of diabetes on the development and progression of long-term complications in insulindependent diabetes mellitus. N Engl J Med; 329: 977-986.
- Yadav S, Parakh A. (2006), Insulin therapy. Indian Pediatr. Oct;43(10):863-72.
